impetigo after actinic keratosis treatment with ingenol mebutate gel: an important complication

نویسندگان

dennis a. porto department of dermatology, henry ford health system, detroit, usa; department of dermatology, henry ford health system, detroit, usa

matteo c lopiccolo department of dermatology, henry ford health system, detroit, usa; the toledo clinic inc, ohio, usa

david j kouba the toledo clinic inc, ohio, usa

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Ingenol Mebutate Gel after Cryotherapy of Actinic Keratosis: When can I Start the Topical Treatment?

Actinic keratosis (AK) is a common dermatological disorder on sun-exposed skin. Its premalignant condition is widely known; therefore both treatment and protection from sunlight are needed to prevent malignant transformation. Field and lesiontargeted therapies can be combined to search a synergistic effect. Here we report our experience with cryotherapy and ingenolmebutate used sequentially, wi...

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Ingenol mebutate: a novel treatment for actinic keratosis

• Ingenol mebutate gel (Picato® gel, LEO Pharma, Ballerup, Denmark) is a novel topical self-applied treatment for nonhyperkeratotic, nonhypertrophic actinic keratoses in adults. • Picato gel (0.05%) is applied to trunk and extremity lesions for 2 consecutive days, and at lower strength (0.015%) applied to face and scalp lesions for 3 consecutive days. • The mechanism of action is rapid inductio...

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New developments in the treatment of actinic keratosis: focus on ingenol mebutate gel

Actinic keratosis is a common disease in older, fair-skinned people, and is a consequence of cumulative ultraviolet exposure. It is part of a disease continuum in photodamaged skin that may lead to invasive squamous cell carcinoma. Treatment options frequently used include cryosurgery and topical pharmacologic agents, which are examples of lesion-directed and field-directed strategies. Ingenol ...

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Evaluation of Ingenol mebutate efficacy for the treatment of actinic keratosis with Antera 3D camera.

OBJECTIVE Cumulative exposure of the skin to ultraviolet radiation promotes mutation in keratinocytes and their abnormal growth led to the formation of scaly lesions, called actinic keratoses (AKs). Its incidence is growing at an emerging rate, becoming a worldwide problem especially for occupational ultraviolet (UV) rays exposure. Detectable lesions are often associated with field changes, wher...

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Efficacy of ingenol mebutate gel for actinic keratosis in patients treated by thiazide diuretics

Actinic keratosis (AK) is considered as superficial squamous cell carcinoma. Chronic sun exposure plays a central role in its pathogenesis. In particular, ultraviolet B radiation causes direct damage to the DNA, producing pyrimidine dimers that suppress the protective role of p53. Other risk factors include advanced age, male sex, and fair skin type. Even some drugs used for treating blood hype...

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Dermoscopy and Reflectance Confocal Microscopy for Monitoring the Treatment of Actinic Keratosis with Ingenol Mebutate Gel: Report of Two Cases.

INTRODUCTION A relatively novel application for dermoscopy and reflectance confocal microscopy (RCM) is their use in the monitoring of topical treatment response for non-melanoma skin cancer. Actinic keratosis (AK) is the early phase of a multistep biologic continuum leading to invasive squamous cell carcinoma. A number of topical therapies are now available for the treatment of AK but their di...

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عنوان ژورنال:
journal of skin and stem cell

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